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antagonist

A drug that attaches to a receptor and blocks it, so the body's own chemicals or other drugs cannot act there.

an-TAG-uh-nist noun

Word parts

ant- againstagon struggle-ist one who

What it means

A drug that fits a receptor without switching it on, and so stops other substances from working at that site. Naloxone is an opioid antagonist that reverses opioids; beta blockers block beta receptors. The opposite is an agonist, a drug that switches a receptor on. In anatomy, an antagonist is also a muscle that works against another, such as the triceps against the biceps.

At a glance

Spanishantagonista
Also writtenantagonists, antagonism

Related terms

opioid analgesic

A strong drug that relieves moderate to severe pain by acting on the brain and spinal cord.

neurotransmitter

A chemical that a nerve cell releases to pass a signal to another nerve, muscle or gland cell.

adrenergic

Relating to nerves and receptors that respond to epinephrine and norepinephrine, or a drug that acts like them.

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