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Dictionary · Drug

donepezil

A drug that raises acetylcholine in the brain, used to ease memory and thinking symptoms in Alzheimer disease.

doe-NEP-eh-zil noun

What it means

A cholinesterase inhibitor for mild to severe Alzheimer diseaseAHLTS-hy-mer dih-ZEEZA brain disease that slowly destroys memory, thinking and the ability to do everyday tasks.Full entry . It does not stop the disease, but may slow the decline in memory and daily function for a time. Common effects are nausea, diarrhea, poor appetite, vivid dreams and a slow heart rate.

For the nurse

It is usually taken at bedtime. Check the pulse and report a slow rate, fainting or dizziness. Watch weight and appetite. Teach the family that benefits are modest and that it should not be stopped suddenly.

At a glance

Drug classcholinesterase inhibitor
Brand namesAricept, Aricept ODT
Also writtenAricept

Related terms

bradycardia

A heart rate slower than normal; in an adult, fewer than 60 beats per minute.

Alzheimer disease

A brain disease that slowly destroys memory, thinking and the ability to do everyday tasks.

neurotransmitter

A chemical that a nerve cell releases to pass a signal to another nerve, muscle or gland cell.

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