What it means
The mucus in the lungs of people with cystic fibrosisSIS-tik fy-BROH-sisAn inherited disease in which the body makes thick, sticky mucus that clogs the lungs, pancreas and other organs.cyst/o sacfibr/o fiber-osis abnormal conditionFull entry is thick partly because of DNA released from dead white blood cells. Dornase alfa is an enzyme that breaks down this DNA, making the mucus thinner and easier to cough up. It is breathed in from a nebulizer, usually once a day. Side effects include hoarse voice, sore throat and chest discomfort.
For the nurse
Keep the vials in the refrigerator and away from light. Do not mix it with other drugs in the nebulizer. It is often given before airway clearance (chest physiotherapy) so the loosened mucus can be cleared.
At a glance
| Drug class | mucolytic (enzyme) |
|---|---|
| Brand names | Pulmozyme |
| Also written | Pulmozyme |
Related terms
cystic fibrosis
An inherited disease in which the body makes thick, sticky mucus that clogs the lungs, pancreas and other organs.
acetylcysteine
A drug used as the antidote for acetaminophen overdose and, when inhaled, to thin thick mucus.