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drug interaction

A change in how a drug works when it is taken with another drug, a food, a drink or a supplement.

drug in-ter-AK-shun noun

What it means

An effect that happens because two substances are taken together. One may make the other stronger, weaker or longer-lasting, or the two may add up to a harmful effect. Examples: warfarin with aspirin raises bleeding risk; grapefruit juice raises the level of some drugs; two sedating drugs together slow breathing; antacids can block absorption of some antibiotics. Herbal products such as St. John's wort cause many interactions.

For the nurse

Ask about every medicine, including over-the-counter drugs, vitamins and herbal products, and check for interactions before giving a new drug. Teach the client which foods or drinks to avoid with their medicines.

At a glance

Spanishinteracción farmacológica
Also writtendrug interactions, drug-drug interaction, drug-drug interactions

Related terms

side effect

An effect of a drug, other than the one it is given for, that is known and expected to happen in some people.

adverse effect

An unwanted and harmful effect of a drug or treatment given at a normal dose.

pharmacokinetics

How the body takes in, spreads, changes and gets rid of a drug over time.

polypharmacy

The use of many medicines at the same time by one person, often defined as five or more.

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