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Dictionary · Drug

fluphenazine

A first-generation antipsychotic drug for schizophrenia, given by mouth or as a long-acting injection.

floo-FEN-uh-zeen nounBoxed warningBeers Criteria

What it means

A high-potency typical antipsychotic of the phenothiazine group that blocks dopamine in the brain. The decanoate form is a long-acting injection given every few weeks, which helps clients who find daily pills hard to take. Movement side effects are common: muscle spasms (acute dystonia), restlessness (akathisia), Parkinson-like stiffness and, after long use, tardive dyskinesiaTAR-div dis-kih-NEE-zhuhA movement disorder with repeated movements a person cannot control, most often of the face, lips and tongue.dys- badkinesi/o movement-ia conditionFull entry . A rare, dangerous reaction is neuroleptic malignant syndrome.

For the nurse

Give the decanoate deep IM, often by Z-track. Watch for stiffness, tremor, restlessness and abnormal mouth or tongue movements, and report high fever with rigid muscles at once. Antipsychotics carry a boxed warning for higher death rates in older adults with dementia.

At a glance

Drug classfirst-generation (typical) antipsychotic, phenothiazine
Brand namesProlixin
Spanishflufenazina
Also writtenProlixin Decanoate, fluphenazine decanoate

Related terms

antipsychotic

A drug used to treat psychosis, such as hallucinations and delusions, in conditions like schizophrenia and bipolar disorder.

tardive dyskinesia

A movement disorder with repeated movements a person cannot control, most often of the face, lips and tongue.

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