What it means
An NMDA receptor antagonist that calms overactive glutamate signals in the brain. It is used in moderate to severe Alzheimer diseaseAHLTS-hy-mer dih-ZEEZA brain disease that slowly destroys memory, thinking and the ability to do everyday tasks.Full entry , often with a cholinesterase inhibitor such as donepezil. It does not stop the disease, but may slow the decline in daily function for a time. Side effects include dizziness, headache, confusion and constipation.
For the nurse
Teach the family what it can and cannot do, and to report new confusion or dizziness. The dose is raised slowly and lowered in severe kidney disease. Extended-release capsules can be opened and sprinkled on applesauce but not crushed or chewed.
At a glance
| Drug class | NMDA receptor antagonist (anti-Alzheimer agent) |
|---|---|
| Brand names | Namenda, Namenda XR |
| Spanish | memantina |
| Also written | Namenda |
Easy to confuse with
methadone
A long-acting opioid drug used to treat opioid use disorder and severe pain.
Related terms
Alzheimer disease
A brain disease that slowly destroys memory, thinking and the ability to do everyday tasks.
dementia
A long-term, usually worsening decline in memory and thinking that is serious enough to affect daily life.