What it means
An antiemetic that blocks serotonin (5-HT3) receptors in the gut and the brain's vomiting center. It is widely used for nausea from chemotherapy, radiation and surgery. It comes as tablets, tablets that melt on the tongue (ODT), and IV or IM injections. Common side effects are headache and constipation; it can also lengthen the QT interval on the ECG.
For the nurse
Ask about heart rhythm problems and check potassium and magnesium in a client at risk, since low levels add to the QT risk. Place the melting tablet on the tongue with dry hands and let it dissolve. Watch for constipation and for headache.
At a glance
| Drug class | antiemetic (serotonin 5-HT3 receptor antagonist) |
|---|---|
| Brand names | Zofran |
| Spanish | ondansetrón |
| Also written | Zofran |
Related terms
nausea
An uneasy feeling in the stomach with the urge to vomit.