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Rho(D) immune globulin

An injection of antibodies given to an Rh-negative person to stop their body from making antibodies against Rh-positive blood.

ROH-dee ih-MYOON GLOB-yoo-lin noun

What it means

A blood product made from donated plasma. If Rh-positive blood from a fetus enters the blood of an Rh-negative pregnant person, their immune system can make antibodies that attack the red blood cells of a future Rh-positive baby. This injection removes the fetal cells before that can happen. It is usually given at about 28 weeks of pregnancy, within 72 hours after the birth of an Rh-positive baby, and after events where blood may mix, such as miscarriage, abortion, ectopic pregnancy, amniocentesis or belly trauma.

For the nurse

Check the client's blood type and antibody screen, and confirm she is Rh-negative and not already sensitized. Give it IM to the mother, never to the newborn, and follow facility policy for blood products, which may include consent and a second checker.

In a chart

"Mother O negative, newborn A positive; RhoGAM 300 mcg IM given in left deltoid at 18 hours postpartum."

At a glance

Drug classimmune globulin
Brand namesRhoGAM, HyperRHO, Rhophylac, WinRho
Spanishinmunoglobulina anti-D
Also writtenRh immune globulin, anti-D immune globulin, RhoGAM

Related terms

vaccine

A product that trains the immune system to protect the body against a specific disease.

red blood cell

A blood cell that carries oxygen from the lungs to the body's tissues; also called an erythrocyte.

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