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Dictionary · Drug

selective serotonin reuptake inhibitor

A type of antidepressant that raises serotonin levels between nerve cells by slowing its reuptake.

suh-LEK-tiv sair-uh-TOH-nin ree-UP-tayk in-HIB-ih-ter nounBoxed warning

What it means

The most often prescribed class of antidepressants, used for depression, anxiety disorders, obsessive-compulsive disorderob-SES-iv kum-PUL-siv dis-OR-derA mental health condition with unwanted thoughts that keep coming back and actions a person feels driven to repeat.Full entry , post-traumatic stress disorderpohst-truh-MAT-ik STRES dis-OR-derA mental health condition that develops after a person lives through or sees a terrifying event.Full entry and other conditions. Examples are fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa) and escitalopram (Lexapro). Full benefit usually takes several weeks. Common side effects include nausea, headache, sleep changes and sexual problems.

For the nurse

The boxed warning covers a higher risk of suicidal thoughts in children, teens and young adults, especially in the first weeks and after dose changes: watch closely and teach the family to report changes in mood or behavior. Teach that it may take 2 to 6 weeks to feel better, not to stop suddenly, and not to combine it with other drugs that raise serotonin, because of serotonin syndromesair-uh-TOH-nin SIN-drohmA drug reaction caused by too much serotonin activity in the nervous system.Full entry . ISMP warns against writing SSRI for "sliding scale regular insulin", because it is read as this drug class.

At a glance

Drug classselective serotonin reuptake inhibitor (SSRI) antidepressant
Brand namesProzac, Zoloft, Paxil, Celexa, Lexapro
AbbreviationsSSRI
Spanishinhibidor selectivo de la recaptación de serotonina (ISRS)
Also writtenselective serotonin reuptake inhibitors, SSRI, SSRIs

Related terms

neurotransmitter

A chemical that a nerve cell releases to pass a signal to another nerve, muscle or gland cell.

mechanism of action

How a drug works in the body: the exact process by which it produces its effect.

suicidal ideation

Thinking about, considering or planning suicide.

serotonin syndrome

A drug reaction caused by too much serotonin activity in the nervous system.

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