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Dictionary · Drug

trimethoprim

An antibiotic used mainly for urinary tract infections, most often combined with sulfamethoxazole.

try-METH-oh-prim noun

What it means

It blocks bacteria from making folic acid, which they need to grow. Alone, it treats some urinary tract infectionYUR-ih-nair-ee TRAKT in-FEK-shunAn infection anywhere in the urinary tract: the kidneys, ureters, bladder or urethra.Full entry . Combined with sulfamethoxazolesul-fuh-meth-OK-suh-zohlA sulfonamide antibiotic, almost always given combined with trimethoprim.Full entry (sold as Bactrim or Septra), it treats urinary infections, some MRSA skin infections and Pneumocystis pneumonia in people with weak immune systems. It can raise blood potassium and creatinine, and cause rash.

For the nurse

Check potassium and kidney function in older adults and clients on drugs that raise potassium. Teach the client to drink plenty of fluids and to report a rash, sore throat or unusual bruising.

At a glance

Drug classantibiotic (folate antagonist)
Brand namesPrimsol; with sulfamethoxazole: Bactrim, Septra
Spanishtrimetoprima
Also writtenPrimsol

Related terms

hyperkalemia

A blood potassium level above normal, over 5.0 mEq/L.

urinary tract infection

An infection anywhere in the urinary tract: the kidneys, ureters, bladder or urethra.

sulfamethoxazole

A sulfonamide antibiotic, almost always given combined with trimethoprim.

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