What it means
A natural chemical released by nerves of the sympathetic nervous system and the adrenal glands. As a drug, it is a vasopressor: given as a continuous IV infusion to raise a dangerously low blood pressure, for example in septic shock. It mainly narrows blood vessels, so it can reduce blood flow to the hands, feet, kidneys and gut.
For the nurse
Give it on an infusion pump, ideally through a central line, and check blood pressure very often as ordered. Watch the IV site closely: if the drug leaks into the tissue, stop the infusion and follow policy; phentolamine is the antidote injected into the area. Check urine output and the color and warmth of fingers and toes.
At a glance
| Drug class | vasopressor; alpha- and beta-adrenergic agonist |
|---|---|
| Brand names | Levophed |
| Spanish | norepinefrina, noradrenalina |
| Also written | noradrenaline, Levophed |
Related terms
epinephrine
A hormone and drug, also called adrenaline, that raises heart rate and blood pressure and opens the airways.
sepsis
A severe whole-body response to an infection that damages the body's own organs.
autonomic nervous system
The part of the nervous system that controls body functions without conscious thought, such as heart rate, breathing and digestion.
neurotransmitter
A chemical that a nerve cell releases to pass a signal to another nerve, muscle or gland cell.