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rhabdomyolysis

The rapid breakdown of damaged skeletal muscle, which releases the muscle's contents into the blood.

rab-doh-my-OL-ih-sis noun

Word parts

rhabd/o rod-shaped (striated)my/o muscle-lysis breaking down

What it means

When skeletal muscle is badly injured, its cells break open and release myoglobin, potassium and the enzyme creatine kinaseKREE-uh-teen KY-nayzAn enzyme found mainly in muscle, measured in the blood to look for muscle damage.Full entry into the blood. Myoglobin can block and damage the kidneys, causing acute kidney injuryuh-KYOOT KID-nee IN-juh-reeA sudden loss of kidney function over hours to days.Full entry , and high potassium can cause dangerous heart rhythms. Causes include crush injuries, very hard exercise, heat illness, lying on the floor for a long time after a fall, seizures and some drugs, including statins.

For the nurse

Give IV fluids as ordered to keep urine output high, measure output hourly, and follow potassium and creatine kinase levels. Report dark, tea-colored urine or a drop in urine output.

Related terms

skeletal muscle

Muscle attached to bones that a person moves by choice, such as the muscles of the arms and legs.

acute kidney injury

A sudden loss of kidney function over hours to days.

statin

A drug that lowers cholesterol by blocking an enzyme the liver uses to make it.

creatine kinase

An enzyme found mainly in muscle, measured in the blood to look for muscle damage.

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