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toxicity

The harm a substance does to the body, or a state in which a drug has built up to a harmful level.

tok-SIS-ih-tee noun

Word parts

tox/o poison-icity state or quality of

What it means

How poisonous something is, and the harm it causes. Drug toxicity happens when the level in the blood rises too high, from too large a dose, kidneys or liver that clear the drug poorly, or drug interactions. Some drugs have a narrow therapeutic range, so the safe level is close to the toxic level; their blood levels are checked, as with digoxindih-JOK-sinA drug that makes the heart beat more strongly and more slowly.Full entry , lithiumLITH-ee-umA mood-stabilizing drug used mainly to treat and prevent the mood episodes of bipolar disorder.Full entry and some antibiotics.

For the nurse

Know the early signs of toxicity for high-risk drugs, check ordered drug levels and kidney function, and hold the dose and report if signs appear.

In a chart

"Lithium level 2.1 mEq/L; client has coarse tremor and vomiting; dose held, provider notified."

At a glance

Spanishtoxicidad
Also writtentoxicities, toxic

Related terms

digoxin

A drug that makes the heart beat more strongly and more slowly.

side effect

An effect of a drug, other than the one it is given for, that is known and expected to happen in some people.

adverse effect

An unwanted and harmful effect of a drug or treatment given at a normal dose.

excretion

The removal of wastes, or of a drug and its breakdown products, from the body.

lithium

A mood-stabilizing drug used mainly to treat and prevent the mood episodes of bipolar disorder.

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