The body: cells, tissues and organs

1Why it matters

Anatomy is the study of the body's structures, the parts you can see and touch and the parts you need a microscope to see. Physiology is the study of how those parts work. The two go together, because the shape of a part fits the job it does.

At the surgical field you use both every day. You hear the surgeon ask for something "deep" or "lateral". You read a scan cut in a plane. You help open a body cavity, and you know what lining you will meet. You hand off a specimen whose label names the site and the side. You choose a toothed or a smooth instrument because of the tissue it will hold. And you help protect the body's balance, which anesthesiaanesthesiaan-us-THEE-zhuhLoss of feeling or sensation, often brought on by drugs so that surgery or a procedure can be done without pain.an- withoutesthesi/o feeling, sensation-ia conditionFull entry Close and a cold room both upset.

This chapter builds the map. It starts with the words for direction and place, then goes small, to the cell, and builds back up through tissues and organs to whole systems. Other chapters teach what this one leaves out: building words from their parts in chapter 1; each body system in chapters 3 to 9 (skin, bone and muscle in 3, nerves and the senses in 4, the heart, blood and lymphlymphLIMFThe clear fluid that flows through the lymphatic vessels and carries white blood cells.Full entry Close in 5, breathing in 6, digestion in 7, the kidneys and reproduction in 8, hormones in 9); germs, infection and the immune system in chapter 10; inflammation, healing, tumors and cancer in chapter 11; paralyzing drugs in chapter 13; incisions and specimen handling in chapter 29; and surgical positions in chapter 31.

2How the body is built

The body is organized in levels. Each level is built from the one below it, and each one is more complex.

1. Chemical: atoms join to make molecules, such as water, proteins and sugars. Molecules are the building blocks of every structure in the body.
2. Cell: the smallest unit that can live and work on its own. Almost everything the body does happens in cells or starts in them.
3. Tissue: a group of similar cells that work together on one job.
4. Organ: a distinct structure made of two or more kinds of tissue, with one or more specific jobs.
5. Organ system: a group of organs that work together on a major job for the body.
6. Organism: the whole living person, in whom every cell, tissue, organ and system works together to keep the person alive and healthy.

The body has trillions of cells and at least 200 different cell types. They differ a great deal in shape and job, but they fall into four main kinds: epithelial cells, connective tissueconnective tissuekuh-NEK-tiv TISH-ooBody tissue that supports, binds together and protects other tissues and organs.Full entry Close cells, muscle cells and neuronsneuronNOOR-onA nerve cell: a cell that carries electrical and chemical signals through the nervous system.neur/o nerveFull entry Close, the nerve cells. Those four kinds of cells make up the four tissue types, which are epithelial, connective, muscle and nervous tissue.

The AST Core Curriculum names 13 body systems. Some textbooks group them differently and count 11. Sorting organs into systems is not exact, because many organs work in more than one system. This course follows the Core Curriculum's list.

3Anatomical position and the words for direction

Anatomical position

To describe the body without confusion, everyone pictures it in the same standard pose, called anatomical position: standing upright, feet flat and pointing forward, arms at the sides, palms facing forward. Every direction is described as if the body were in this pose, however the patient is actually lying. So the palm side of the wrist is always the front of the wrist, even when the hand rests palm down on an arm board.

A patient lying face up is supine, and a patient lying face down is prone. You will help place patients in these and other positions; chapter 31 teaches them.

Directional terms

Directional terms tell where one part is compared with another. They come in pairs of opposites.

You will hear these words all day in surgery. The Trendelenburg positionTrendelenburg positiontren-DEL-en-burg puh-ZISH-unA position in which the client lies on the back with the bed tilted so the head is lower than the feet.Full entry Close, which tilts the head down, moves the abdominal and pelvic organs cephalad, toward the head, so the surgeon can see the pelvis.

On paper, the words protect the patient. The surgical site is marked so there is no doubt about where the incision goes, which helps prevent wrong-site surgery. A specimen label names the site and the side, left or right. When a surgeon places a marking stitch or dye on a specimen to show which edge was superior, lateral or medial, the scrub keeps those marks intact on the field, so the pathologist can tell which edge is which.

Body planes

A plane is an imaginary flat surface that passes through the body. A cut along a plane is called a section. Scans such as CTcomputed tomographykum-PYOO-tid toh-MOG-ruh-feeAn imaging test that uses x-rays and a computer to make cross-section pictures of the inside of the body.tom/o cut, slice-graphy process of recordingFull entry Close give pictures of the body in sections, and you can read them only if you know which plane they were cut in.

• Sagittal plane: a vertical plane that splits the body or an organ into a left part and a right part.
• Midsagittal plane: the sagittal plane that runs exactly down the middle, making equal right and left halves. It is also called the median plane. A sagittal plane off to one side, making unequal parts, is a parasagittal plane.
• FrontalfrontalFRUN-tulRelating to the front of the body, or to the forehead and the bone or brain area behind it.Full entry Close plane, also called the coronal plane: a vertical plane that divides the body into front (anterior) and back (posterior) parts.
• Transversetransversetrans-VERSLying across something, at a right angle to its length.Full entry Close plane: a horizontal plane that divides the body into upper and lower parts. It makes cross sections, and it is also called the axial plane.
• Oblique plane: a plane that crosses the body at an angle, neither horizontal nor vertical.

You will see these planes in the OR. A CT scan of the head is shown as a stack of transverse slices. A spine surgeon describes scoliosisscoliosisskoh-lee-OH-sisA sideways curve of the spine.scoli/o crooked, curved-osis abnormal conditionFull entry Close, a sideways curve of the spine, as a curve in the frontal plane, and kyphosiskyphosisky-FOH-sisAn outward curve of the upper spine that makes the back look rounded or hunched.kyph/o hump-osis conditionFull entry Close as a curve in the sagittal plane. To correct them with rods, the surgeon bends the rods to shape and rotates them.

4The abdomen: quadrants and regions

To describe where pain, a mass or an organ sits, the team divides the abdomen into four quadrants or nine regions. The quadrants are the simpler and more common way.

The four quadrants

One vertical line and one horizontal line cross at the umbilicus, the navel, and make four quadrants.

The quadrants show up in the OR. The appendix sits in the right lower quadrant, and a McBurney incision for an open appendectomyappendectomyap-en-DEK-tuh-meeSurgery to remove the appendix.append appendix-ectomy surgical removalFull entry Close is made there, splitting the oblique muscle rather than cutting it. In laparoscopiclaparoscopiclap-uh-roh-SKOP-ikDone through a few small cuts in the abdomen with a thin camera and long instruments, instead of one large opening.lapar/o abdomen-scopic viewingFull entry Close surgery, port sites are named by quadrant too, such as a left upper quadrant port.

Appendectomy26 instruments · 1 photo

The nine regions

For a more exact location, two vertical lines and two horizontal lines make a grid of nine regions, like a tic-tac-toe board. The vertical lines drop from the middle of each collarbone. One horizontal line runs just below the ribs and the other just above the pelvis.

The names come from word parts. Hypo- means below and chondr means cartilagecartilageKAR-tih-lijFirm, smooth, rubbery tissue that cushions joints and gives shape to parts such as the ear, nose and windpipe.chondr/o cartilageFull entry Close, so the hypochondriac regions lie below the rib cartilages. Epi- means upon and gastr means stomach, so the epigastric region lies over the stomach. You may also hear the groin regions called inguinal, the lumbar regions called the flanks, and the hypogastric region called pubic or suprapubic.

5Body cavities and their linings

The body's organs sit in compartments called cavities, which hold and protect them. The two largest are the dorsaldorsalDOR-sulHaving to do with the back of the body, or the top of the hand or foot.Full entry Close cavity at the back and the ventralventralVEN-trulOn or toward the front, belly side of the body.ventr/o belly, front-al relating toFull entry Close cavity at the front. Each is divided into smaller cavities.

The dorsal cavity

• CranialcranialKRAY-nee-ulRelating to the skull, or toward the head end of the body.crani/o skull-al relating toFull entry Close cavity: inside the skull. It holds the brain.
• Spinal cavity, also called the vertebral cavity: inside the vertebral columnvertebral columnVER-tuh-brul KOL-umThe spine: the column of small bones (vertebrae) that runs down the back and surrounds the spinal cord.vertebr joint, vertebra-al relating toFull entry Close. It holds the spinal cord.

The two connect without a break, just as the brain and spinal cord do. Bone protects them, and so does cerebrospinal fluidcerebrospinal fluidser-uh-broh-SPY-nul FLOO-idThe clear, watery fluid that bathes and cushions the brain and spinal cord.cerebr/o brainspin spine-al relating toFull entry Close, a clear fluid that cushions the brain and cord.

The ventral cavity

• Thoracicthoracicthuh-RAS-ikRelating to the chest, or to the middle part of the spine.thorac/o chest-ic relating toFull entry Close cavity: the chest, inside the rib cage. It holds the lungs, each in its own pleuralpleuralPLOOR-ulHaving to do with the pleura, the thin two-layer membrane that covers the lungs and lines the chest wall.pleur/o pleura-al relating toFull entry Close cavity, and the heart. The heart sits in the mediastinum, the central space between the two lungs, along with the great vessels, the tracheatracheaTRAY-kee-uhThe windpipe: the tube that carries air from the throat to the lungs.Full entry Close and the esophagusesophagusih-SOF-uh-gusThe muscular tube that carries food and liquid from the throat to the stomach.esophag/o esophagusFull entry Close.
• DiaphragmdiaphragmDY-uh-framThe dome-shaped sheet of muscle under the lungs that is the main muscle of breathing; also the flat side of a stethoscope.Full entry Close: the dome of muscle under the lungs. It is the floor of the chest and walls it off from the abdomen and pelvis below.
• Abdominopelvic cavity: the largest cavity in the body. No wall divides it, but it is described in two parts. The abdominal cavity holds most of the digestive organs, such as the stomach, liver, gallbladder and intestines. The pelvic cavity below holds the bladder, part of the large intestine and the internal reproductive organs.

The ventral cavity gives organs room to change size. The lungs fill, the heart beats and the stomach stretches without crowding their neighbors.

The serous membranes

The walls and organs of the ventral cavity are covered by thin membranes called serousserousSEER-usThin, watery and clear to pale yellow, like the fluid part of blood.Full entry Close membranes. Each one has two layers: the parietalparietalpuh-RY-uh-tulRelating to the wall of a body cavity; also names a lobe of the brain and two bones of the skull.pariet/o wall-al relating toFull entry Close layer lines the cavity wall, and the visceralvisceralVIS-er-ulHaving to do with the internal organs, especially those in the chest and belly.viscer/o internal organs-al relating toFull entry Close layer covers the organs (the viscera). A thin film of slippery serous fluid between the layers cuts frictionfrictionFRIK-shunThe rubbing of one surface against another, such as skin against bed sheets.Full entry Close as the organs move.

• Pleura: surrounds each lung. The parietal pleura lines the chest wall, and the visceral pleura covers the lung.
• Pericardiumpericardiumpair-ih-KAR-dee-umThe thin, two-layered sac that surrounds the heart.peri- aroundcardi/o heart-um a structureFull entry Close: surrounds the heart.
• Peritoneumperitoneumpair-ih-toh-NEE-umThe thin membrane that lines the belly cavity and covers most of the organs inside it.peri- aroundton stretched-eum a structureFull entry Close: lines the abdominal cavity and covers many abdominal organs. Folds of peritoneum connect the abdominal organs; one fold, the mesentery, attaches to the back wall of the abdomen and fans out to cover the small intestine.

Some organs lie behind the peritoneum, in the retroperitoneum: the kidneys, the adrenal glandsadrenal glanduh-DREE-nul GLANDOne of two small glands that sit on top of the kidneys and make hormones such as cortisol, aldosterone and epinephrine.ad- toward, nearren/o kidney-al relating toFull entry Close and the uretersureterYOOR-uh-terOne of the two tubes that carry urine from the kidneys down to the bladder.Full entry Close. A layer of peritoneum separates them from the abdominal organs in front.

After inflammation or infection, strands of scar tissue called adhesionsadhesionad-HEE-zhunA band of scar tissue that joins two surfaces inside the body that are normally separate.ad- towardhes stick-ion conditionFull entry Close can form between the peritoneum and the abdominal organs. During surgery the surgeon may have to release them, which is called lysis of adhesions.

Opening a cavity

Many operations are named for the cavity they open. A craniotomycraniotomykray-nee-OT-uh-meeSurgery in which a piece of the skull is removed to reach the brain, and usually put back at the end.crani/o skull-tomy cutting intoFull entry Close opens the cranial cavity through the scalp and skull. A thoracotomythoracotomythor-uh-KOT-uh-meeA surgical cut through the chest wall to reach the lungs, heart or other organs in the chest.thorac/o chest-tomy cutting intoFull entry Close opens the thoracic cavity. A laparotomylaparotomylap-uh-ROT-uh-meeSurgery that opens the abdomen through a large cut to reach the organs inside.lapar/o abdomen-tomy cutting intoFull entry Close opens the abdominal cavity, and an exploratory laparotomy is done to look inside when less invasive tests have not found the cause of a problem.

Pro Basic Craniotomy33 instruments · 6 photosPro Thoracotomy47 instruments Exploratory Laparotomy32 instruments · 1 photo

An open cavity also loses heat. In open chest and abdominal surgery, moisture evaporates from the exposed organs, and the longer the organs lie open in a cool room, the colder the patient can get. You will see why that matters later in this chapter.

6The cell

A cell is a tiny, fluid-filled package wrapped in a membrane. Inside, small working parts called organelles each do their own jobs, the way organs do for the whole body. Nearly every body cell carries the full set of the person's DNADNAdee-en-AY (said as letters)Deoxyribonucleic acid: the molecule in cells that carries the genetic instructions for growth and function.Full entry Close.

The cell membrane

The cell membrane, also called the plasmaplasmaPLAZ-muhThe pale yellow liquid part of the blood, which carries the blood cells, proteins, nutrients and wastes.Full entry Close membrane, wraps every cell. It keeps the cell's contents in and controls what passes in or out.

It is built of two layers of fat-like molecules called phospholipidsphospholipidfos-foh-LIP-idA fat molecule with a phosphate group that forms the double layer around every cell.phospho phosphorus, phosphatelip/o fat-id a form ofFull entry Close. Each phospholipid has a head that is drawn to water and two tails that push water away. The heads face the watery fluid inside and outside the cell, and the tails tuck into the middle. Cholesterol and many proteins sit in this double layer. Some proteins are channels that let certain particles through. Others are receptorsreceptorrih-SEP-terA structure on or in a cell that a specific chemical, such as a hormone or drug, attaches to in order to act.Full entry Close that catch chemical messages, and others are markersmarkerMAR-kerSomething that can be measured, such as a substance in the blood, that shows a disease or body process is present.Full entry Close that tell the immune system the cell belongs to this person. Those markers are one reason a donated organ can be rejected.

The membrane is selectively permeable: it lets some things through and keeps others out. Small, uncharged molecules such as oxygen and carbon dioxidecarbon dioxideKAR-bun dy-OK-sideA gas made by the body's cells as waste, carried in the blood to the lungs and breathed out.Full entry Close slip straight through. Sugar, charged particles called ions and most other water-loving substances need help to cross.

Passive transport moves substances without using the cell's energy.

• Diffusiondiffusiondih-FYOO-zhunThe movement of particles from an area where they are more concentrated to one where they are less concentrated.dif- apartfus pour-ion processFull entry Close: particles spread from where they are crowded to where they are scarce, until they are even. Oxygen diffuses into cells and carbon dioxide diffuses out.
• Facilitated diffusion: diffusion through a protein channel or carrier, for substances too big or too charged to cross alone, such as glucose and sodium.
• Osmosisosmosisoz-MOH-sisThe movement of water across a membrane from a less concentrated solution to a more concentrated one.Full entry Close: the diffusion of water across a membrane. Water moves toward the side with more dissolved particles.
• Filtrationfiltrationfil-TRAY-shunThe passing of fluid through a filter or membrane, which holds back larger particles; in the kidneys, the first step in making urine.filtr strain through-ation processFull entry Close: pressure pushes fluid and the small particles in it through a membrane, as blood pressure pushes fluid out of the smallest blood vessels into the tissues.

Active transport uses energy, from a molecule called ATPATPay-tee-PEE (said as letters)Adenosine triphosphate: the molecule that stores and delivers energy for nearly every process in a cell.Full entry Close, to move substances, usually from where there is little to where there is more.

• Pumps: the sodium-potassium pump pushes sodium out of the cell and pulls potassium in. Nerve cellsneuronNOOR-onA nerve cell: a cell that carries electrical and chemical signals through the nervous system.neur/o nerveFull entry Close run these pumps constantly.
• Endocytosis: the membrane folds around something outside the cell and pinches off to bring it in. Phagocytosisphagocytosisfag-oh-sy-TOH-sisThe process by which some white blood cells swallow and destroy germs, dead cells and debris.phag/o eatcyt/o cell-osis processFull entry Close, "cell eating," takes in large particles such as bacteria; pinocytosis, "cell drinking," takes in fluid.
• Exocytosis: the reverse. A sac inside the cell joins the membrane and releases its contents outside, the way gland cells release enzymesenzymeEN-zimeA protein that speeds up a chemical reaction in the body without being used up.Full entry Close and hormones.

Osmosis matters at the back table. A fluid with the same concentration of particles as the cell is isotonicisotoniceye-soh-TON-ikHaving the same concentration of dissolved particles as blood, so water does not move into or out of cells.iso- equalton/o tension-ic relating toFull entry Close, and cells keep their normal shape in it. In a fluid with more particles, a hypertonic one, cells lose water and shrivel. In a fluid with fewer particles, a hypotonic one, cells take in water, swell and can burst. Irrigationirrigationeer-ih-GAY-shunWashing out a wound, body cavity, tube or eye with a steady flow of liquid.Full entry Close fluids are chosen to suit the body tissue they touch, and normal saline is isotonic. Plain distilled water is so hypotonic that, used to irrigate during a prostateprostatePROS-taytA walnut-sized gland below the bladder in males that surrounds the urethra and makes part of the fluid in semen.Full entry Close resectionresectionrih-SEK-shunSurgery to remove part of an organ or tissue.re- back, againsect to cut-ion processFull entry Close, it can burst red blood cells.

Cytoplasm and the organelles

Everything between the cell membrane and the nucleus is the cytoplasm: a jelly-like fluid called cytosol, plus the organelles floating in it. A web of protein fibers, the cytoskeleton, holds the cell's shape and keeps the organelles in place.

The nucleus

The nucleus is the largest organelle and the control center of the cell, because it holds the instructions for making every protein. Most cells have one nucleus. Skeletal muscleskeletal muscleSKEL-uh-tul MUS-ulMuscle attached to bones that a person moves by choice, such as the muscles of the arms and legs.Full entry Close cells have many, and mature red blood cells have none.

• Nuclear membrane, or nuclear envelope: a double membrane around the nucleus. Small openings called nuclear pores let RNARNAar-en-AY (said as letters)Ribonucleic acid: a molecule in cells that copies genetic instructions from DNA and helps build proteins.Full entry Close and proteins pass between the nucleus and the cytoplasm.
• Nucleolus: a dark spot inside the nucleus that makes the RNA used to build ribosomes.
• Chromatin and chromosomes: the DNA in the nucleus is wound around proteins into threads called chromatin. When the cell gets ready to divide, the chromatin coils up tightly into chromosomes so it can be moved safely. A human body cell has 46 chromosomes, holding about 22,000 genes.

Nucleic acids: DNA and RNA

DNA and RNA are nucleic acidsnucleic acidnoo-KLAY-ik AS-idA large molecule, DNA or RNA, that carries genetic information in living cells.Full entry Close, the molecules that store and use the body's genetic instructions.

DNA (deoxyribonucleic acid) is shaped like a long, twisted ladder, the double helix. Its side rails are sugar and phosphate. Each rung is a pair of bases, and the bases always pair the same way: adenine (A) with thymine (T), and cytosine (C) with guanine (G). The order of the bases is the genetic code. A gene is a stretch of DNA that holds the code for one protein, and each set of three bases stands for one amino acidamino aciduh-MEE-noh AS-idOne of the small building blocks that join together in chains to make proteins.Full entry Close, the building blocks of proteins.

Proteins do almost all of the cell's work. Many are enzymes, which speed up the cell's chemical reactions; others form the cell's structure.

RNA (ribonucleic acid) carries out DNA's instructions. It differs from DNA in three ways: it is usually a single strand, its sugar has one more oxygen atom, and it uses the base uracil (U) in place of thymine. Three kinds of RNA build proteins together.

• Messenger RNA (mRNAmRNAem-ar-en-AY (said as letters)Messenger RNA: a molecule that carries a gene's instructions from DNA to the parts of the cell that build proteins.Full entry Close): copies the code of one gene inside the nucleus, a step called transcription, and carries the copy out to the cytoplasm.
• Ribosomal RNA (rRNA): joins with proteins to form the ribosome, the workbench where the protein is built.
• Transfer RNA (tRNAtRNAtee-AR-en-ay (said as letters)Transfer RNA: small RNA molecules that carry amino acids to the ribosome while a cell builds a protein.Full entry Close): reads the mRNA code three bases at a time and brings the matching amino acid to the ribosome. There each new amino acid is joined to the last, building a chain, a step called translation, until a stop signal ends the protein.

Cellular respiration: how cells get energy

Cells run on ATP (adenosine triphosphate). A cell stores energy by making ATP, then breaks ATP apart to release a small, controlled burst of energy where work needs doing, such as a muscle fiber contracting or a pump moving sodium. Cellular respiration is how cells make ATP from food. The sugar glucose is the body's most readily available fuel.

1. Glycolysisglycolysisgly-KOL-ih-sisThe first stage of breaking down glucose inside a cell to release energy.glyc sugar-lysis breaking downFull entry Close: in the cytoplasm, one glucose molecule is split into two smaller molecules called pyruvate. This gives a net gain of two ATP, and it does not need oxygen.
2. Anaerobic oxidation, without oxygen: when oxygen is short, the pyruvate is turned into lactic acidlactateLAK-taytA substance made when cells break down glucose for energy; its blood level is a common lab test.lact/o milk (lactic acid was first found in sour milk)-ate a salt of an acidFull entry Close so glycolysis can keep going. This works for seconds to a few minutes. Hard-working muscles do it when oxygen cannot reach them fast enough, and red blood cells, which have no mitochondria, make all their ATP this way.
3. Aerobic oxidation, with oxygen: inside the mitochondria, the pyruvate is broken down completely. Carbon dioxide is given off as waste, oxygen is used up and becomes water, and about 36 ATP are made from each glucose, far more than glycolysis alone. This is why you must keep breathing.

Brain cells need a steady, high supply of ATP. Without oxygen, brain damage is likely within about five minutes.

You will see this in surgery. A pneumatic tourniquet stops blood flow to a limb so the surgeon has a bloodless field. Tissue cut off from its blood flow runs short of oxygen, so its cells switch to anaerobic oxidation and lactic acid builds up. When the cuff comes down, that acid and other waste rush into the patient's circulation, and the effect grows with the length of tourniquet time. Because the harm grows with time, AST recommends keeping cuff time as short as possible. Its general recommendation for adults is an inflation time of 60 minutes on an arm and 90 minutes on a leg. A CSTCSTsee-es-tee (said as letters)Certified Surgical Technologist, a credential for surgical technologists; in maternity care, contraction stress test.Full entry Close in the assistant circulator role helps watch the cuff's pressure and time.

Cell division

Most body cells divide to grow and to replace old cells, and billions divide every day. Cells of the skin and the lining of the digestive tract divide very often, because they are worn away constantly. A few kinds rarely or never divide, including most neurons and skeletal and cardiac musclecardiac muscleKAR-dee-ak MUS-ulThe muscle tissue that makes up the walls of the heart.cardi/o heart-ac relating toFull entry Close cells.

This shapes how tissue heals. Skeletal muscle can be repaired by special cells called satellite cells, but dead heart musclemyocardiummy-oh-KAR-dee-umThe thick middle layer of the heart wall, made of heart muscle that contracts to pump blood.my/o musclecardi/o heart-um structureFull entry Close is replaced by scar tissue.

DNA replication comes first. The two strands of the DNA ladder unzip, and each strand is used as a pattern to build a new partner strand. Each of the two new DNA molecules keeps one old strand and one new one. Enzymes check the new strands and fix most mistakes, because each new cell needs an exact copy.

The life of a cell is called the cell cycle. Most of the time a cell is in interphase: it grows, does its normal work and, before dividing, copies its DNA. Then comes mitosismitosismy-TOH-sisCell division that makes two new cells, each with the same full set of chromosomes as the original.mit thread (the chromosomes look like threads)-osis processFull entry Close, the division of the nucleus, in four stages:

1. Prophase: the chromatin coils into visible chromosomes, each one now an X of two identical copies joined together. The nuclear membrane breaks down, and the two centrosomes move to opposite sides and send out a spindle of protein tubes.
2. Metaphase: the chromosomes line up across the middle of the cell.
3. Anaphase: the two copies of each chromosome are pulled apart to opposite ends of the cell.
4. Telophase: a new nuclear membrane forms around each set of chromosomes, making two nuclei.

Last comes cytokinesis, when a ring of protein fibers pinches the cytoplasm in two. The result is two daughter cells, each with the same 46 chromosomes as the parent.

When the controls on cell division fail, cells keep dividing and can form a tumor. Chapter 11 teaches tumors and cancer.

Meiosismeiosismy-OH-sisCell division that makes eggs or sperm, each with half the usual number of chromosomes.meio- less, smaller-osis processFull entry Close is a different kind of division that makes only eggs and sperm, the gametes. The DNA is copied once, then the cell divides twice, making four cells. Each one has only 23 chromosomes, half the usual number, and each is genetically different from the others. When a sperm and an egg join, the new cell has a full set again, one copy of each chromosome from each parent.

New technology: growing cells for surgery

A stem cellstem cellSTEM SELAn unspecialized cell that can divide to make more of itself and develop into specialized cells.Full entry Close is an unspecialized cell that can keep dividing and, under the right conditions, become a specialized cell. Stem cells are grouped by how many cell types they can become:

• Totipotent: the first cells made after an egg is fertilizedfertilizationfer-tuh-lih-ZAY-shunThe joining of a sperm and an egg to form a single new cell, the start of a pregnancy.Full entry Close. They can become any cell, enough to build a whole person.
• Pluripotent: embryonic cells that can become any tissue, but not a whole person.
• Multipotent: cells that can become a few related cell types. The adult stem cells in bone marrowbone marrowbone MAIR-ohThe soft, spongy tissue inside bones that makes blood cells.Full entry Close, which make all the blood cells, are multipotent, and so are stem cells in the skin and in umbilical cord blood.

Stem cells already help the body heal: scattered stem cells in connective tissueconnective tissuekuh-NEK-tiv TISH-ooBody tissue that supports, binds together and protects other tissues and organs.Full entry Close supply new cells to repair it after an injury. Researchers hope to use stem cells to repair damaged tissue: in cell-based therapy, stem cells are turned into specialized cells in a lab dish and injected into the patient, though many obstacles remain. Embryonic stem cells can become almost any cell, but the patient's immune system may reject them, and taking them raises ethicalethicalETH-ih-kulHaving to do with what is morally right, or acting in line with accepted moral principles.Full entry Close questions. A patient's own adult stem cells are not rejected, but they can become fewer cell types.

The Core Curriculum lists cell cloning of cartilagecartilageKAR-tih-lijFirm, smooth, rubbery tissue that cushions joints and gives shape to parts such as the ear, nose and windpipe.chondr/o cartilageFull entry Close and skin as new technology. A clone is a group of cells that all come from one cell, and the term is used for cells grown in tissue culture. Two operations already put a patient's own skin or cartilage cells, multiplied in a lab, back into the patient:

• Skin: for a patient with large burns and too little healthy skin to graftgraftGRAFTTissue or a man-made material moved into place in surgery to replace or repair a damaged part.Full entry Close, a small piece of the patient's skin can be sent to a lab, where its skin cells are grown into a sheet of new epidermisepidermisep-ih-DER-misThe thin outer layer of the skin.epi- on, uponderm/o skinFull entry Close, called a cultured epithelial autograft.

• Cartilage: to repair a hole in the cartilage of a knee, a surgeon removes a small piece of the patient's cartilage through an arthroscope. Its cartilage cells, the chondrocytes, are grown in a lab, and usually 3 to 6 weeks later a second, open operation places them into the defect under a suturedsutureSOO-cherA stitch, or the thread used to stitch, that holds the edges of a wound or incision together.Full entry Close patch. This is called autologous chondrocyte implantationimplantationim-plan-TAY-shunThe attachment of a fertilized egg to the lining of the uterus, the start of a pregnancy.im- inplant to set-ation the process ofFull entry Close.

7Tissues

What makes a tissue

Cells of the same kind, working side by side on the same job, make a tissue. The Core Curriculum points to four things that make a tissue:

• A collection of like cells: the cells share a shape and an origin and are arranged in an orderly pattern.
• A common, specialized job: such as covering, connecting, moving or signaling.
• Cell attachments: cells are joined by junctions. Tight junctions seal neighbors together so nothing leaks between them. Anchoring junctions, such as desmosomes, hold cells firmly together. Gap junctions are tiny tunnels that let ions pass from cell to cell, so a group of cells can work as one.
• Material between the cells: the extracellular matrix, made by the cells themselves, is a ground substance crossed by protein fibers. Epithelial tissue has almost none; connective tissueconnective tissuekuh-NEK-tiv TISH-ooBody tissue that supports, binds together and protects other tissues and organs.Full entry Close has a great deal.

The body has four types of tissue: epithelial, connective, muscle and nervous.

Epithelial tissue

Epithelial tissue, or epitheliumepitheliumep-ih-THEE-lee-umThe tissue that covers the body's surfaces and lines its organs, vessels and cavities.Full entry Close, is made of sheets of cells. It covers the outside of the body, lines the body's cavities, hollow organs and passageways, and forms much of the body's glandular tissue.

• Its cells are packed tightly with almost no matrix between them, held together by junctions.
• One surface faces the outside or the inside of a hollow organ, and the other rests on a thin basement membrane that joins it to the connective tissue below.
• It has no blood vessels of its own. Food and oxygen reach it by diffusiondiffusiondih-FYOO-zhunThe movement of particles from an area where they are more concentrated to one where they are less concentrated.dif- apartfus pour-ion processFull entry Close from the tissue underneath.
• Many epithelia replace damaged and dead cells quickly.
• It protects the body, controls what passes in, and secretes and absorbsabsorptionub-ZORP-shunThe taking in of a substance, such as a drug or a nutrient, into the bloodstream.Full entry Close. Everything that enters the body crosses an epithelium.

Epithelium is named by the shape of its cells and the number of layers. Squamous cells are flat and thin, cuboidal cells are as wide as they are tall, and columnar cells are taller than they are wide. Simple epithelium is one layer of cells; stratified epithelium has several layers and is named by the shape of the top layer.

Epithelium that covers or lines a surface is lining epithelium. Epithelium made mostly of cells that secrete is glandular epithelium. Goblet cells, single cells that make mucus, are mixed into some simple and pseudostratified columnar epithelium. Larger glands grow from epithelium too: exocrine glands release their products through ducts, and endocrine glandsendocrine glandEN-doh-krin GLANDA gland that releases hormones straight into the blood instead of through a tube or duct.endo- within-crine to secreteFull entry Close release hormones into the fluid around them, to be carried in the blood.

Connective tissue

Connective tissue binds the body's parts together, supports and protects them, carries materials around the body in blood and lymphlymphLIMFThe clear fluid that flows through the lymphatic vessels and carries white blood cells.Full entry Close, and stores energy as fat. Its cells are spread out in a large amount of matrix.

Connective tissue typically has three parts: cells, ground substance and fibers.

• Cells: the most common is the fibroblast, which makes the fibers and the ground substance. Fat cells (adipocytes) store fat. Immune cells such as macrophagesmacrophageMAK-roh-fayjA large white blood cell in the tissues that swallows and digests germs, dead cells and debris.macro- large-phage eaterFull entry Close and mast cellsmast cellmast selAn immune cell in the tissues that releases histamine and other chemicals during allergic reactions and inflammation.Full entry Close also move through connective tissue.
• Fibers: collagencollagenKOL-uh-jenThe main structural protein of the body, which gives strength to skin, bones, tendons, ligaments and scar tissue.coll/a glue-gen producingFull entry Close fibers are strong and resist stretching, which gives tendons and ligaments their strength. Elastic fibers spring back after stretching, as skin does. Reticular fibers form a fine net that supports soft organs such as the liver and spleenspleenspleenAn organ in the upper left abdomen that filters the blood and helps fight infection.splen/o spleenFull entry Close.
• Ground substance: a clear, gel-like material that fills the space around the cells and fibers. In bone it is hardened with minerals.

The Core Curriculum also lists dense fibrousfibrousFY-brusMade of or containing tough threads (fibers), especially of connective tissue.fibr/o fiber-ous full of, relating toFull entry Close connective tissue. Fibrous tissue is another name for dense connective tissue, which is mostly collagen fibers and comes in the regular and irregular forms in the table. FasciafasciaFASH-ee-uhA sheet or band of tough connective tissue that covers and separates muscles and organs.fasci/o bandFull entry Close and tendon are examples.

Blood supply is one factor in how fast a tissue heals. Cartilage has no blood vessels and heals very slowly. Tendons have a poor blood supply and also heal slowly. Bone is rich in blood vessels and heals in a relatively short time.

Connective tissue also changes how you handle it. Fascia, tendon and cartilage are strong and slippery, and with few blood vessels to injure, they can be held with toothed clamps such as a Kocher. Fat makes instruments slippery, so you wipe them with a damp sponge, and the surgeon uses toothed forcepsforcepsFOR-sepsA hand instrument with two blades or arms used to grasp, hold or pull tissue or objects.Full entry Close to hold fat while suturing.

Muscle tissue

Muscle tissue is excitable, which means it responds to a signal, and contractile, which means it can shorten and pull. It can also stretch and then spring back to its resting length. There are three types.

Skeletal muscleskeletal muscleSKEL-uh-tul MUS-ulMuscle attached to bones that a person moves by choice, such as the muscles of the arms and legs.Full entry Close makes up about 40 percent of body mass, and the heat of its contractions helps keep body temperature steady. Shivering is skeletal muscle contracting on its own to make heat.

At the field, surgeons separate or pull muscle aside along its fibers rather than cut across it whenever they can, because cut muscle is slow to regain its function. Muscle also holds suturessutureSOO-cherA stitch, or the thread used to stitch, that holds the edges of a wound or incision together.Full entry Close poorly.

Nervous tissue

Nervous tissue is excitable too. It receives information, sends electrical signals and passes messages to other cells. It has two kinds of cells: neuronsneuronNOOR-onA nerve cell: a cell that carries electrical and chemical signals through the nervous system.neur/o nerveFull entry Close and neuroglia.

A neuron has three main parts:

• the cell body, which holds the nucleus and most of the organelles
• dendritesdendriteDEN-driteOne of the short, branching parts of a nerve cell that receive signals from other cells.dendr- treeFull entry Close, thin branches that receive signals and carry them toward the cell body
• one axonaxonAK-sonThe long, thin part of a nerve cell that carries electrical signals away from the cell body.Full entry Close, a long fiber that carries the signal away from the cell body. Many axons are wrapped in myelinmyelinMY-uh-linThe fatty covering wrapped around many nerve fibers that protects them and speeds up their signals.myel/o marrow, the spinal cord (myelin was first seen as a marrow-like core of nerves)Full entry Close, an insulating layer made by neuroglia.

The axon ends at a synapsesynapseSIN-apsThe tiny gap where a nerve cell passes a signal to another nerve cell, a muscle or a gland.Full entry Close, a tiny gap between the neuron and the next cell, which may be another neuron, a muscle fiber or a gland. Chemicals called neurotransmittersneurotransmitterNOOR-oh-trans-mit-erA chemical that a nerve cell releases to pass a signal to another nerve, muscle or gland cell.neur/o nervetrans- acrossmitt send-er one that doesFull entry Close carry the message across the gap.

Neurons are grouped by the direction their signals travel. AfferentafferentAF-er-entCarrying something toward a center or organ, such as nerve signals toward the brain.af- (ad-) towardfer carry-ent doingFull entry Close, or sensory, neurons carry information from the body to the brain and spinal cord. EfferentefferentEF-er-entCarrying something away from a center or organ, such as nerve signals from the brain to the muscles.ef- (ex-) away fromfer carry-ent doingFull entry Close, or motor, neurons carry commands away from the brain and spinal cord to muscles and glands. An easy way to remember: afferent signals arrive, efferent signals exit.

Neuroglia, or glial cells, support and protect the neurons. In fact, the brain and spinal cord are made mostly of neuroglia. There are six types:

• in the brain and spinal cord: astrocytes, the most common, which support neurons and help form the barrier between the blood and the brain; oligodendrocytes, which make myelin; microglia, which defend against infection; and ependymal cells, which make cerebrospinal fluidcerebrospinal fluidser-uh-broh-SPY-nul FLOO-idThe clear, watery fluid that bathes and cushions the brain and spinal cord.cerebr/o brainspin spine-al relating toFull entry Close
• in the nerves of the body: satellite cells, which support neurons, and Schwann cells, which make myelin

How a muscle contracts

Each skeletal muscle fiber is packed with long strands called myofibrils, and each myofibril is a chain of tiny units called sarcomeres. The sarcomere is the smallest part of a muscle that contracts. It holds two kinds of protein filaments: thin filaments made of actinactinAK-tinA protein that forms thin threads inside muscle cells and works with myosin to make a muscle contract.Full entry Close, and thick filaments made of myosin. Two more proteins, troponintroponinTROH-puh-ninA protein found in heart muscle cells; its level in the blood is a lab test for heart muscle damage.Full entry Close and tropomyosin, sit on the actin and control when it can be grabbed. The neat, repeating pattern of these filaments is what gives skeletal and cardiac musclecardiac muscleKAR-dee-ak MUS-ulThe muscle tissue that makes up the walls of the heart.cardi/o heart-ac relating toFull entry Close their stripes.

The sliding filament mechanism works like this:

1. A signal from a motor neuronmotor neuronMOH-ter NOOR-onA nerve cell that carries signals from the brain or spinal cord out to a muscle to make it move.Full entry Close makes an electrical wave run along the muscle fiber.
2. The wave makes the fiber's sarcoplasmic reticulum, a special kind of smooth ERERee-AR (said as letters)An abbreviation with more than one meaning: emergency room, or extended-release when written after a drug name.Full entry Close, release stored calcium.
3. Calcium binds to troponin, and tropomyosin slides off the binding sites on the actin.
4. The heads of the myosin filaments grab the actin, forming cross-bridges, and pull the actin toward the center of the sarcomere.
5. ATPATPay-tee-PEE (said as letters)Adenosine triphosphate: the molecule that stores and delivers energy for nearly every process in a cell.Full entry Close lets each myosin head let go, reset and grab again farther along, like hands pulling in a rope one grip at a time. Without ATP, the heads cannot let go.
6. The thin filaments slide past the thick ones, and the sarcomere shortens.

When the nerve signal stops, calcium is pumped back into the sarcoplasmic reticulum, tropomyosin covers the binding sites again, and the muscle relaxes. A muscle that runs out of ATP also stops contracting. Smooth musclesmooth musclesmooth MUS-ulMuscle that works without conscious control and lines hollow organs such as the stomach, intestines, bladder, airways and blood vessels.Full entry Close uses calcium in a different way, but every muscle needs ATP to keep contracting.

This chain of events has an OR emergency behind it. Malignant hyperthermiamalignant hyperthermiamuh-LIG-nunt hy-per-THER-mee-uhA rare inherited reaction to certain general anesthesia drugs in which the muscles' metabolism speeds up out of control.mal- badhyper- above normaltherm heat-ia conditionFull entry Close is a dangerous reaction to some anestheticanesthetican-us-THET-ikA drug that causes loss of feeling, with or without loss of consciousness.an- withoutesthesi/o feeling, sensation-ic relating toFull entry Close gases and the muscle relaxant succinylcholinesuccinylcholinesuk-sih-nil-KOH-leenA fast, short-acting drug that relaxes and paralyzes the muscles, used to place a breathing tube.Full entry Close. In 50 to 70 percent of families who carry it, the faulty gene is the one for the channel in the sarcoplasmic reticulum that releases calcium for contraction. Chapter 13 teaches how the team responds.

Neuromuscular excitability

Excitable cells, neurons and muscle fibers, carry signals as electricity. At rest, the inside of a nerve cell is negative compared with the outside, about minus 70 millivolts, and the sodium-potassium pump keeps it that way. This is the resting membrane potential.

A nerve impulseimpulseIM-pulsAn electrical signal that travels along a nerve or through the heart muscle; also, a sudden urge to act.Full entry Close is a wave of electrical change that runs along the membrane:

1. A stimulus opens channels in the membrane, and sodium ions rush in. The inside becomes less negative, then briefly positive. This is depolarizationdepolarizationdee-poh-ler-ih-ZAY-shunThe change in electrical charge across a nerve or muscle cell's membrane that sets off a signal or a contraction.de- removal, reversalpolar having opposite charges-ization processFull entry Close.
2. Then potassium channels open, potassium ions flow out, and the inside turns negative again. This is repolarization.
3. This quick swing, called an action potential, triggers the same change in the next patch of membrane, so the signal travels along the whole cell.

The neuromuscularneuromuscularnoor-oh-MUS-kyuh-lerHaving to do with both nerves and muscles, or with the place where a nerve meets a muscle.neur/o nervemuscul/o muscle-ar relating toFull entry Close junction is where a motor neuron meets a skeletal muscle fiber, and every skeletal muscle fiber has one. The nerve ending and the muscle do not touch; a tiny gap called the synaptic cleft lies between them.

1. The nerve impulse reaches the end of the motor neuron, and the neuron releases the neurotransmitter acetylcholineacetylcholineuh-see-tul-KOH-leenA chemical messenger that nerves release to signal muscles, glands and other nerves.Full entry Close (ACh).
2. ACh crosses the cleft and binds to receptorsreceptorrih-SEP-terA structure on or in a cell that a specific chemical, such as a hormone or drug, attaches to in order to act.Full entry Close on the muscle fiber, at the motor end plate.
3. The receptors open channels, sodium enters, and the muscle fiber fires its own action potential, which starts contraction.
4. An enzymeenzymeEN-zimeA protein that speeds up a chemical reaction in the body without being used up.Full entry Close, acetylcholinesterase, breaks down the ACh almost at once, so the muscle does not keep contracting.

Skeletal muscle contracts only when a nerve tells it to. Heart and smooth muscle can also respond to hormones and local signals, and the heart sets its own beat.

This is why paralyzing drugs work as they do. Neuromuscular blocking agentsneuromuscular blocking agentnoor-oh-MUS-kyuh-ler BLOK-ing AY-juntA drug that blocks signals from nerves to skeletal muscles, so the muscles relax completely and cannot move.Full entry Close act at this junction. They are given with general anesthesiageneral anesthesiaJEN-er-ul an-es-THEE-zhuhDrug-induced loss of consciousness and feeling over the whole body, so a person feels nothing and is not aware during surgery.an- withoutesthesi/o feeling, sensation-ia conditionFull entry Close to relax the skeletal muscles, and they have little effect on heart or smooth muscle, so the heart keeps beating. A drug that blocks acetylcholinesterase can help reverse some of them. Chapter 13 teaches these drugs.

Membranes of the body

A tissue membrane is a thin sheet of tissue that covers the body, lines a cavity or passageway, or wraps an organ. There are two groups.

Epithelial membranes are epithelium resting on connective tissue:

• Mucous membranes line the passages that open to the outside: the digestive, respiratory, urinary and reproductive tracts. A coat of mucus protects them.
• Serous membranes line the closed cavities and cover the organs inside them: the pleurapleuralPLOOR-ulHaving to do with the pleura, the thin two-layer membrane that covers the lungs and lines the chest wall.pleur/o pleura-al relating toFull entry Close, the pericardiumpericardiumpair-ih-KAR-dee-umThe thin, two-layered sac that surrounds the heart.peri- aroundcardi/o heart-um a structureFull entry Close and the peritoneumperitoneumpair-ih-toh-NEE-umThe thin membrane that lines the belly cavity and covers most of the organs inside it.peri- aroundton stretched-eum a structureFull entry Close. Their thin serous fluid cuts frictionfrictionFRIK-shunThe rubbing of one surface against another, such as skin against bed sheets.Full entry Close.
• The cutaneouscutaneouskyoo-TAY-nee-usHaving to do with the skin.cutane/o skin-ous relating toFull entry Close membrane is the skin, a stratified squamous epithelium on connective tissue.

Connective tissue membranes are made only of connective tissue. One is the synovial membrane, which lines movable joints such as the shoulder and knee and makes synovial fluidsynovial fluidsih-NOH-vee-ul FLOO-idThe thick, slippery fluid inside movable joints that lets the bones move smoothly.Full entry Close, a slippery liquid that lets the bones move with little friction.

8Organs and organ systems

What makes an organ

An organ is a distinct structure built from two or more kinds of tissue that work as one unit to do one or more specific jobs. It is one level more complex than a tissue. A skeletal muscleskeletal muscleSKEL-uh-tul MUS-ulMuscle attached to bones that a person moves by choice, such as the muscles of the arms and legs.Full entry Close is an organ: muscle fibers, blood vessels, nerve fibers and connective tissueconnective tissuekuh-NEK-tiv TISH-ooBody tissue that supports, binds together and protects other tissues and organs.Full entry Close wrapped together. The Core Curriculum uses four organs to show how tissues combine.

• Stomach: its wall has four layers. The inner lining, the mucosamucosamyoo-KOH-suhThe moist lining of body passages that open to the outside, such as the mouth, nose, gut and bladder.Full entry Close, has an epitheliumepitheliumep-ih-THEE-lee-umThe tissue that covers the body's surfaces and lines its organs, vessels and cavities.Full entry Close that makes protective mucus, with glands that make gastric juice. Under it, the submucosa is dense connective tissue carrying blood and lymphlymphLIMFThe clear fluid that flows through the lymphatic vessels and carries white blood cells.Full entry Close vessels. Next comes the muscularis, smooth musclesmooth musclesmooth MUS-ulMuscle that works without conscious control and lines hollow organs such as the stomach, intestines, bladder, airways and blood vessels.Full entry Close in three layers that churn and mix food. The outer layer, the serosa, is serousserousSEER-usThin, watery and clear to pale yellow, like the fluid part of blood.Full entry Close membrane.
• Heart: its wall has three layers. The epicardium outside is the visceralvisceralVIS-er-ulHaving to do with the internal organs, especially those in the chest and belly.viscer/o internal organs-al relating toFull entry Close layer of the pericardiumpericardiumpair-ih-KAR-dee-umThe thin, two-layered sac that surrounds the heart.peri- aroundcardi/o heart-um a structureFull entry Close. The thick myocardiummyocardiummy-oh-KAR-dee-umThe thick middle layer of the heart wall, made of heart muscle that contracts to pump blood.my/o musclecardi/o heart-um structureFull entry Close in the middle is cardiac musclecardiac muscleKAR-dee-ak MUS-ulThe muscle tissue that makes up the walls of the heart.cardi/o heart-ac relating toFull entry Close built on a framework of collagencollagenKOL-uh-jenThe main structural protein of the body, which gives strength to skin, bones, tendons, ligaments and scar tissue.coll/a glue-gen producingFull entry Close, with its own blood vessels and nerves. The endocardium inside is endothelium, simple squamous epithelium, that lines the chambers and covers the valves.
• Brain: nervous tissue, neuronsneuronNOOR-onA nerve cell: a cell that carries electrical and chemical signals through the nervous system.neur/o nerveFull entry Close and neuroglia, protected by the meningesmeningesmuh-NIN-jeezThe three thin layers of tissue that cover and protect the brain and spinal cord.mening/o membraneFull entry Close, layers of connective tissue whose tough outer layer is the duraduraDOOR-uhThe tough outer layer of the membranes that cover the brain and spinal cord.Full entry Close mater.
• Nerves: bundles of axonsaxonAK-sonThe long, thin part of a nerve cell that carries electrical signals away from the cell body.Full entry Close, the long fibers of neurons, held together by layers of connective tissue and fed by blood vessels.

Compare the four and you see that each one mixes the tissue types in its own way. The heart and the stomach both have a muscle layer in their walls, but the heart's is cardiac muscle and the stomach's is smooth muscle. The brain and the nerves are built around nervous tissue, wrapped and protected by connective tissue.

What organ systems do together

Organ systems share the work of keeping every cell alive. The Core Curriculum names four things they do together.

Exchange of materials. Cells need oxygen and nutrients brought in and carbon dioxidecarbon dioxideKAR-bun dy-OK-sideA gas made by the body's cells as waste, carried in the blood to the lungs and breathed out.Full entry Close and wastes carried away. Everything that enters the body crosses an epithelium, and exchange is fastest where the epithelium is thinnest. Gases pass through the simple squamous lining of the lungs' air sacs and the capillariescapillaryKAP-ih-lair-eeOne of the tiniest blood vessels, joining the smallest arteries to the smallest veins.Full entry Close. Nutrients pass from the intestine into the blood. Fluid filters out of capillaries to feed the tissues, and the kidneys filter wastes out of the blood. Blood and lymph carry all of it around the body.

Homeostasishomeostasishoh-mee-oh-STAY-sisThe body's way of keeping its inside conditions, such as temperature, fluids and blood sugar, steady.home/o same-stasis standing still, staying the sameFull entry Close. Homeostasis is the body's steady inner balance. Body temperature, blood pressure, blood sugar and many other values each have a set point, with a narrow normal range around it. The set point for body temperature is about 37°C (98.6°F). When a value drifts too far, illness follows.

Regulation and feedbackfeedbackFEED-bakInformation about a result that is sent back to change what happens next, in the body or between people.Full entry Close. The body keeps its balance mostly by negative feedback, which reverses a change. A negative feedback system has three parts:

1. a sensor, or receptorreceptorrih-SEP-terA structure on or in a cell that a specific chemical, such as a hormone or drug, attaches to in order to act.Full entry Close, that measures a value
2. a control center, often in the brain, that compares the value with the normal range
3. an effector that acts to bring the value back, such as the sweat glands or the blood vessels of the skin

Body temperature is the classic example. When you are too warm, the brain widens the blood vessels in the skin to shed heat and turns on sweating. When you are too cold, it narrows those vessels to keep heat in the core and makes the muscles shiver, and hormones raise heat production in the cells. Blood sugar works the same way: when it rises, the pancreaspancreasPAN-kree-usA long, flat gland behind the stomach that makes digestive enzymes and the hormones insulin and glucagon.pan- allcreas fleshFull entry Close releases insulininsulinIN-suh-linA hormone made by the pancreas that lets the body's cells take in glucose, also made as a medicine.Full entry Close, cells take up the sugar, and the insulin stops as the level falls.

Positive feedback does the opposite: it pushes a change further until an end point is reached. It is normal only when there is a definite end. In childbirth, stretching of the cervix triggers the hormone oxytocinoxytocinok-sih-TOH-sinA hormone that makes the uterus contract and releases breast milk; also given by IV to start or strengthen labor and control bleeding after birth.Full entry Close, which makes the uterus contract harder, which stretches the cervix more, until the baby is born. Blood clottingclottingKLOT-ingThe process by which blood thickens into a gel to plug a damaged vessel and stop bleeding; also called coagulation.Full entry Close works the same way: each step releases more clotting substances until the bleeding vessel is sealed.

Response to the environment. The body senses changes outside it and inside it and adjusts, such as sweating on a hot day or moving away from danger.

Homeostasis in the OR

Keeping a patient warm is homeostasis you can help with. The body normally holds its core temperature within a very small range, run by the brain's temperature center. Surgery attacks that balance from every side.

• General anesthesiageneral anesthesiaJEN-er-ul an-es-THEE-zhuhDrug-induced loss of consciousness and feeling over the whole body, so a person feels nothing and is not aware during surgery.an- withoutesthesi/o feeling, sensation-ia conditionFull entry Close blunts the brain's temperature control. In planned (nonemergency) surgery, this effect of anesthesiaanesthesiaan-us-THEE-zhuhLoss of feeling or sensation, often brought on by drugs so that surgery or a procedure can be done without pain.an- withoutesthesi/o feeling, sensation-ia conditionFull entry Close is the main cause of unplanned hypothermiahypothermiahy-poh-THER-mee-uhA body temperature that has fallen below the normal range.hypo- belowtherm/o heat-ia conditionFull entry Close.
• Anesthesia also widens blood vessels, so warm blood moves from the core out to the skin and loses heat.
• The patient lies on a cold table, in a cool room, sometimes with cold fluids running in, and an open chest or abdomen loses heat as moisture evaporates.
• With a spinal or epiduralepidural anesthesiaep-ih-DOOR-ul an-us-THEE-zhuhPain relief or numbness from an anesthetic drug given through a thin catheter into the space just outside the covering of the spinal cord.epi- upon, overdur/o dura (the tough covering of the spinal cord)-al relating toFull entry Close block, the numb part of the body cannot shiver or narrow its blood vessels.

AST sets the line at 36°C: a core temperature below 36°C is hypothermia. An estimated more than half of surgical patients in the United States become hypothermic. Hypothermia is linked to slower wound healingwound healingwoond HEE-lingThe body's process of repairing damaged skin and tissue.Full entry Close, more surgical site infections, weaker clotting and more bleeding, and anestheticanesthetican-us-THET-ikA drug that causes loss of feeling, with or without loss of consciousness.an- withoutesthesi/o feeling, sensation-ic relating toFull entry Close drugs that last longer. That is why the team works to keep patients warm, with steps such as warmed fluids and forced-air warming.

9When tissue growth goes wrong

Healthy tissues grow, shrink and repair themselves in a controlled way. The Core Curriculum names seven ways growth can go wrong. Most of the names end in -plasia, which means formation or development; the prefix tells you what kind. Hyper- means excessive, hypo- means deficient, a- means without, and dys- means bad.

Hyperplasia and hypertrophy are easy to mix up. Both make an organ bigger: hyperplasia by adding cells, hypertrophy by enlarging the cells already there. BPH goes by both names: the Core Curriculum calls it benign prostatic hypertrophy, and other references call it benign prostatic hyperplasia. Both names mean the same disease.

BPH is often treated with a transurethral resection of the prostatetransurethral resection of the prostatetrans-yoo-REE-thrul rih-SEK-shun of the PROS-taytSurgery that removes part of the prostate gland with an instrument passed up through the urethra.trans- throughurethr/o urethra-al relating toresection cutting outFull entry Close (TURP), in which the surgeon removes the extra prostate tissue with a resectoscope passed up the urethra.

Dysplasia and anaplasia are also steps on the scale pathologists use to grade the cells of many tumors. Mildly dysplastic cells look only a little different from normal; severe dysplasia looks very abnormal; anaplastic cells are so primitive that it is hard to tell what tissue they came from. The more abnormal the cells, the worse the outlook.

Cervical dysplasia is one reason for two procedures, which remove the abnormal tissue so a pathologist can examine it. A LEEP (loop electrosurgicalelectrosurgeryee-LEK-troh-SUR-jer-eeUsing high-frequency electric current through a handheld tool to cut tissue or seal bleeding vessels during surgery.Full entry Close excisionexcisionek-SIZH-unCutting out tissue, such as a growth or damaged area, during surgery.Full entry Close procedure) removes the abnormal cells with a thin, electrified wire loop, and the loop's size depends on how much dysplasia there is and on the surgeon's preference. A cold knife cone biopsy cuts out a cone of tissue around the opening of the cervix with a scalpel and scissors. Before the biopsy, the surgeon may paint the cervix with Lugol solution, a mild iodineiodineEYE-uh-dyneA mineral the thyroid gland uses to make thyroid hormone; it is also used to kill germs on the skin and in some contrast dyes.Full entry Close stain that shows where the dysplasia is. Do not confuse it with Monsel solution, another brown liquid on the same back table: it is a mixture containing acids, used to stop bleeding, and painted on by mistake it can damage the biopsy area.

Tumors, benign and malignant, and how cancer spreads are taught in chapter 11.

10Tissue layers at the field

Everything in this chapter comes together when the surgeon makes an incision. The abdominal wall is built of these layers, from the outside in:

1. Skin: stratified squamous epitheliumepitheliumep-ih-THEE-lee-umThe tissue that covers the body's surfaces and lines its organs, vessels and cavities.Full entry Close on top of the dermisdermisDER-misThe thick layer of skin under the epidermis that holds blood vessels, nerves, hair roots and glands.derm/o skinFull entry Close, which is dense irregular connective tissueconnective tissuekuh-NEK-tiv TISH-ooBody tissue that supports, binds together and protects other tissues and organs.Full entry Close.
2. Subcutaneous tissuesubcutaneous tissuesub-kyoo-TAY-nee-us TISH-ooThe layer of fat and loose connective tissue under the skin that attaches the skin to muscle.sub- undercutane/o skin-ous relating toFull entry Close: fatty tissue, adipose tissueadipose tissueAD-ih-pohs TISH-ooBody fat: connective tissue made mostly of fat cells that store energy.adip/o fat-ose full ofFull entry Close mixed with loose areolar tissue, from a quarter inch to more than 8 inches thick.
3. FasciafasciaFASH-ee-uhA sheet or band of tough connective tissue that covers and separates muscles and organs.fasci/o bandFull entry Close: tough connective tissue that covers the muscles. The layer over the front of the muscles is the anterior fascia.
4. Muscle: skeletal muscleskeletal muscleSKEL-uh-tul MUS-ulMuscle attached to bones that a person moves by choice, such as the muscles of the arms and legs.Full entry Close. Behind it lies another layer of fascia, the posterior fascia.
5. Peritoneumperitoneumpair-ih-toh-NEE-umThe thin membrane that lines the belly cavity and covers most of the organs inside it.peri- aroundton stretched-eum a structureFull entry Close: the serousserousSEER-usThin, watery and clear to pale yellow, like the fluid part of blood.Full entry Close membrane lining the abdominal cavity, just beneath the posterior fascia.

The surgeon closes the wound layer by layer, and each tissue behaves differently:

• Peritoneum is thin and heals fast. If the posterior fascia over it is closed well, it may not need suturessutureSOO-cherA stitch, or the thread used to stitch, that holds the edges of a wound or incision together.Full entry Close at all.
• Fascia is the body's main supporting soft tissue. It heals slowly and takes most of the stress on a healing wound, so it is closed securely with strong sutures.
• Muscle holds sutures poorly. It is usually split or pulled aside rather than cut, so it often needs no closure.
• Subcutaneoussubcutaneoussub-kyoo-TAY-nee-usUnder the skin; in the fatty layer between the skin and the muscle.sub- undercutane/o skin-ous relating toFull entry Close fat holds sutures poorly too. It is where most wound infections start, because fatty tissue has weak defenses.
• Skin is closed last. A fine stitch just under the skin can close it neatly, because the fascia is carrying the tension.

Healing speed follows the tissue too. Many epithelia replace their cells quickly; the lining of the bladder covers a suture line within about 5 days. Bone, with its rich blood supply, heals fairly quickly. CartilagecartilageKAR-tih-lijFirm, smooth, rubbery tissue that cushions joints and gives shape to parts such as the ear, nose and windpipe.chondr/o cartilageFull entry Close and tendons, with little or no blood supply, heal slowly. Fascia heals slowly as well.

Chapter 25 teaches sutures and how to choose them, and chapter 29 teaches incisions and how the scrub follows the surgeon through the layers.

Check yourself5 quick questions

Free for everyone. Pick an answer for each, then check them all at once.

In the ORWhere you'll use this